PO-05-085 ENHANCED PAUSE ALGORITHM FOR INSERTABLE CARDIAC MONITOR REDUCES CLINICAL REVIEW BURDEN

A critical feature of an Insertable Cardiac Monitor (ICM) is to identify clinically significant pauses/bradycardic events in patients (pts) with unexplained syncope. Reducing the number false positive pause episodes will reduce clinic review workload. To evaluate enhanced detection algorithm and clinical burden evaluating while maintaining high relative sensitivity increasing specificity. The development set consisted 1033 real world stored LUX-Dx (Boston Scientific) ICM (347 pts) which were selected include more low signal noise ratio (SNR). Another independent test 728 Pause (93 was randomly from a large pool sequestered patient episode data adjudicated by two experts until agreement as uses proprietary two-step detect/confirm process: step 1 detects when R-R interval longer than programmed threshold, 2 confirms (or rejects) suspected after analyzing for broadband myopotential signal-to-noise ratios (SNR) (undersensing). Using (1033 episodes), we have this reject pauses caused amplitude signals. (FP) reduction 62.5% Development 48.6% Test set. Further, pt-level FP ranged 31.3 - 74.1%. No previously detected true positives eliminated either or sets. This maintained sensitivity, exhibited substantial pauses, would decrease device clinics preserving detect important events.Tabled 1DatasetNumber PatientsNumber episodesRelative Sensitivity (%)Reduction (%)Development347103310062.574.1Test9372810048.631.3 Open table new tab